تأثیر الکادمیوم والسیلینیوم على الوظیفة الخصیة وإصابة الأنسجة فی فئران ذکور

The effect of the sub lethal dose of cadmium chloride CdCh 7mglkgl body I weight ) was investigated on the testis and some sperm parameters in rats .. To evaluate the effect of cadmium exposure as CdCh, was orally administered to mature male rats( 250-300g I body weight) for 28 days and the effects on the sperm count , sperm motility , sperm abnormality , sperm death percentages and testes weight, as well as testicular histology were observed. To evaluate the beneficial action of Selenium against Cadmium chloride-induced reduced sperm count and sperm abnormalities and testes injury in albino rats , an additional two groups of rats were treated for same period with SeCiz 8m/kgl body weight ) and Cd - Se combination · respectively to determine the reversibility of Cd-induced changes The sperm counts, sperm motility, sperm abnormality and sperm ) death percentages were significantly decreased following 28th day of CdCh treatment, but were unaffected by Se and Cd- Se exposures. The testicular, epididymis, prostate and seminal vesicle weight were noticeably reduced with Cd-treatment as compared to control. The changes caused by cadmium are mostly recovered by Se administration. Cadmiu·m chloride exposure injures the fertility parameters of male rats and the effects are reversible due to Se supplementation. On the other hand, co-administration of Se at the above mentioned dose to Cadmium treated rats led to the most significant decline in testes tissue damage alorig with elevated ·sperm count and . reduction in the percentage of abnormal spenn population. The protective action of Se and the antagonistic effect of both Se and Cadmium induced testes tissue damage are discussed.