Effect of Aqueous Extract of Capparis spinosa on Serum Antioxidant Status in Paracetamol Treated Rats

Protective effect of aqueous extract of Capparis spinosa was studied on paracetamol induced liver damage in rats by administrating the rats with 1gm/ kg of body weight of paracetamol for 21days. Pretreatment rats with 100 and 200 mg / kg of body weight of Capparis spinosa extract protected rats against paracetamol liver injury lead to significantly increasing of reduced glutathione ( GSH ), catalase (CAT) and superoxide dismutase (SOD), and significantly lowering lipid peroxidation (LPO), manoldialdehyde (MDA), cholesterol and triglyceride levels .
The elevation in GSH ,CAT and SOD and reduction LPO and MDA by using aqueous extract of Capparis spinosa comparing with posetive control and returning the biochemical parameters to normalization indicated that the aqueous extract of Capparis spinosa posses strong protective property against paracetamol- induced liver damage in rats.