Histological Effect of Escherichia coli Strains Isolated From Children Diarrhoea Cases on Intestinal Mucosa of Infant Mouse

In this study strains of Escherichia coli that isolated from children diarrhoea cases had been improved to produce different enterotoxines, heat stable enterotoxin ( ST ) and heat labil enterotoxin ( LT ) inducing positive responses by biological tests such as suckling infant mouse and rapid skin permeability test ( for ST enterotoxin ) and delayed permeability test of rabbit. ( for LT enterotoxin ) Histological effect of crud culture of Escherichia coli on the mucosal intestine of infant mouse had been studied and showed significant tissue damage .lncluding detachment Exfoliation and sloughing of the surtace epithial cell of mucosa of infat mouse.
These data Supported the idea that the enterotoxin is an important virulance factor in Escherichia coli associated diarrhoea that attak the mucosal intestine of infant mouse and microvilli of it .