Gabapentin's impact on the immunohistochemistry response of CASP1, CASP3, and CASP8 proteins in the liver of male albino rats.

Gabapentin is a recently authorized anti-seizure medication for the treatment of sciatic and inflammatory nerve pain. The present investigation examined the adverse impacts of gabapentin on the hepatocytes of white male rats. The present research project included 15 animals. The rats were split into three sets (5 animals each), the first being the untreated set, which received purified water, and the other two sets receiving the medication at levels ranging from 21.8 and 43.6 mg/kg for two months. The activity of CASP1, CASP3, and CASP8 proteins was assessed to detect inflammation and programmed death in the liver cells. The first test set's liver sections (21.8 mg/kg) exhibited a notable positive reaction to the CASPE1 protein. The entrance region and the hepatocyte cytoplasm, however, demonstrated a very significant positive response in the second test set (43.6 mg/kg). The CASP3 protein elicited a significant positive response in the hepatic cells of the liver of the first test set and a strong positive response in the liver of the second test set. A significant positive response to the CASP8 protein was seen in the first test set of liver sections, whereas an even greater positive response was seen in the second test set of sections. In conclusion, gabapentin is toxic to liver cells when used over extended periods and in excessive amounts. Its effects occur at the protein level by activating pathways linked to inflammation and programmed death