Development of the Humoral Immunity on Infection by Tuberculosis Using Guinea Pigs as Experimental Animals

This study was carried to clarify the development of the humoral immunity due to infection by Tuberculosis through artificial infection with three Mycobacterium types using Guinea Pigs as experimental animals. Results indicate that the Humoral immunity (Antibodies Level), which measured by ELISA serology technique (Enzym-Linked Immuno Sorbant Assay), arise progressively and stimulated evidently during the third week of infection, and it found that quickness of passing over the Cut-Off Level (means Tuberculiosis infection is positive by the used ELISA technique) depends on the type of injected Tubercle bacilli and the quickest was the local isolate Mycobacterium tuberculosis (day 26) then M. bovis (day 29) and standard strain M. tuberculosis.