Synthesis of 1,2,4-Oxadiazolidine and Isoxazolidine Derivatives from Addition of Isocyanates and Alkenes to Nitrones

Some new heterocyclic compounds of 1,2,4-oxadiazolidine-5-one derivatives
[3a-m] were synthesized from the reaction of nitrone compounds with some isocyanates of amino acid esters in good yields.
The reaction of nitrone compounds with cyclooctene and tetrahydrophthalic anhydride gave oxazolidine derivatives [4a-d]. The synthesized compounds were formed via 1,3-cycloaddition reaction of isocyanates and alkenes to nitrones. The I.R. spectral data of the synthesized compounds were also discussed.