Relationship of Angiotensin Converting Enzyme 2(ACE2) to Antioxidants and Lipid level in Patients with Heart Diseases

The study included the relation between angiotensin-converting enzyme ACE2 and some of the biochemical parameters related to the heart diseases (reduced Glutathione (GSH), Arylesterase (ARE), ceruloplasmin, malondialdehyde (MAD), Cholesterol, Triglyceride (TG), low-density lipoprotein (LDL), very low-density lipoprotein (VLDL), high-density lipoprotein (HDL), Atherogenic Index(AI), Antiatherogenic Index(AAI) in the serum of the patients compared with control group, the results demonstrated a significant increase in the activity of ACE2 in patients (0.69 ± 0.22 ng/ml) compared with the activity in control group (0.47 ± 0.17 ng/ml) , while the result showed a significant decrease in the concentration of GSH, HDL and ARE activity. A significant increase had been shown in the concentration of ceruloplasmin, TG, LDL, VLDL, and AI, AAI index. Non-significant difference in MAD and  holesterol in patients compared with the healthy group. The results also showed that there was an increase of ACE2 activity in smoking and non-smoking patients compared control group, also an increase of ACE2 activity with increasing body weight or BMI, the Correlation coefficient showed a non-significant correlation between ACE2 and the biochemical parameters measured in patients and control groups.